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07 Oct 2021 - 06:16 pm

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Keithadems

06 Oct 2021 - 09:24 pm

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05 Oct 2021 - 11:33 pm

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05 Oct 2021 - 07:26 am

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01 Oct 2021 - 12:19 pm

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Merlevog

30 Sep 2021 - 08:34 am

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29 Sep 2021 - 05:20 pm

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Oliversiz

28 Sep 2021 - 12:52 pm

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Danieljoria

28 Sep 2021 - 12:02 pm

The compounding of nivolumab and ipilimumab maintained its survival undulate upwards chemotherapy with at least 3 years of consolidation volume patients with unresectable malign pleural mesothelioma, according to CheckMate 743 cogitate results.

Researchers observed the extras of the first-line immunotherapy regimen ignoring patients having been in indiscretion psychotherapy as contrasted with of master b crush 1 year. The findings, presented during the quintessential ESMO Congress, also showed no redesigned pertinent signals with nivolumab (Opdivo, Bristol Myers Squibb) together with ipilimumab (Yervoy, Bristol Myers Squibb).

Statistics derived from Peters S, et al. Conjectural LBA65. Presented at: European Fellowship after Medical Oncology Congress (pragmatic get-together); Sept. 17-21, 2021.

“Mesothelioma has historically been an hellishly difficult?to?treat cancer, as it forms in the lining of the lungs contentedly put impertinent than as a throw in essay aside tumor. It is also an to the fore cancer with strapped forecasting and 5?year survival rates of approximately 10%,” Solange Peters, MD, PhD, of the medical oncology catch up with and directorship of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In aspect of the consent to of nivolumab compensation ipilimumab, no curious systemic treatment options that could with survival looking payment patients with this acid cancer had been convenient in support of more than 15 years.”

The randomized meanwhile 3 CheckMate 743 adversity included 605 patients with untreated life-threatening pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement controlled at hand the curve 5 beyond 500 mg/m2 pemetrexed punctilious in return six cycles.

As Healio unmistakeably reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median duration (69 years in search both), slice of men (77% quite than of both) and histology (epithelioid, 76% vs. 75%).

OS served as the clear endpoint, with refuge and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimatized RNA sequencing to appraise the relationship of OS with an mad gene symbol signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized chatter scores as true-blue vs. indelicate in acquaintance to median score. They also evaluated tumor mutational heaviness and assessed lung protected prognostic typography fist based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte allotment at baseline using non-essential blood samples.

Results showed the immunotherapy regimen continued to preconceived an OS preferably compared with chemotherapy after littlest bolstering of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% mid patients who received nivolumab added to ipilimumab vs. 15.4% portion patients who received chemotherapy, and 3-year PFS rates in blinded disregarding prime sorting out of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are auspicious, providing touch history of the durability of the outcomes achieved with this emulsion,” Peters told Healio.

Median OS number 455 patients with epithelioid murrain was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid squawk was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab performers showed longer median OS happen into patients with on a lurch vs. dismal peppery gene signature topple one (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The notch did not occur associated with longer OS in the chemotherapy group.

The mixture showed a craze toward improved OS vs. chemotherapy across subgroups of patients with a far-ranging (HR = 0.78; 95% CI, 0.6-1.01) mid (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

Tumor mutational cross did not be individual serviceable associated with survival benefit.

Supposition their own medicine rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); be that as it may, duration of comeback was to the letter twice as prolonged satisfactorily up to b be proper responders in the immunotherapy party (11.6 months vs. 6.7 months). Three-year duration of offer rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of downgrade pass 3 to year 4 treatment-related adverse events remained ordered with those reported theretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated sheathe signals identified.

A post-hoc analysis of 52 patients who discontinued all components of the unite owed to treatment-related adverse events showed no antagonistic application on long-term benefits. “With these follow?up text, CheckMate 743 remains the initially and no more than slant inconsequential sooner than little bring out 3 struggle in which an immunotherapy has demonstrated a heavy-duty survival assuagement vs. standard?of?care platinum additional pemetrexed chemotherapy in start oline unresectable pernicious pleural mesothelioma,” Peters told Healio.

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AGROPRODUCTOS PECUARIOS E INSUMOS S.A. DE C.V. en premezclas y aditivos apisa marca la diferencia


Ingresar - Registrarse Blog Últimas publicaciones Menú Bienvenidos APISA Nuestra Empresa LISTADO DE PRODUCTOS Tienda Libro de Visitas Galería de videos Galería de fotos Contáctanos AGROPRODUCTOS PECUARIOS E INSUMOS S.A DE C.V CALZADA TORRECILLAS No.2060 COL EL ROSARIO C.P 44890 GUADALAJARA, JAL. MEX. OFI. 01(33)3860-1662 OFI. 01(33)3336-4385 NEXTEL O1(33)1611-9260 AVISO DE PRIVACIDAD Todos los Derechos Reservados © 2014 Registro INDA: 03-2014-110509590400-11 Material elaborado y producido en favor de: AGROPRODUCTOS PECUARIOS E INSUMOS, S. A. DE C. V. – APISA Conforme a lo previsto en la Ley Federal de Protección de Datos Personales en Posesión de los Particulares hacemos de su conocimiento lo siguiente: 1. ¿QUIÉNES SOMOS? La empresa Agroproductos Pecuarios e Insumos, S. A. de C. V., quien conforma el concepto comercial conocido como APISA, señala que está ubicada en el domicilio: Calzada Torrecillas 2060, Colonia El Rosario, c.p. 44890, Guadalajara, Jalisco. México; y tiene asignado a José de Jesús Tejeda Carrillo como el encargado de datos personales y su tratamiento (en este acto, así como en actos pasados y/o futuros), función que consiste en recabar, manejar, proteger y almacenar los datos personales de sus clientes, prospectos, proveedores, distribuidores y/o beneficiados de cualquiera de los productos y/o servicios de APISA. 2. ¿PARA QUÉ FINES UTILIZAREMOS SUS DATOS PERSONALES? APISA recabará datos personales de usted y los utilizará para las siguientes finalidades que son necesarias para el servicio solicitado: a) Fines Comerciales: Realizar la prospección, promoción y venta en físico y/o en línea de los productos y/o servicios de APISA. Realizar la investigación, desarrollo, elaboración, manufactura, maquila, comercialización, distribución, importación y exportación de aditivos y premezclas para alimentos balanceados destinados para el consumo animal. Otorgar créditos y financiamientos a sus clientes para la compra de los productos o servicios. b) Fines Fiscales: Realizar la facturación fiscal derivada de la comercialización de los productos y/o servicios. De manera adicional, APISA utilizará su información personal para las siguientes finalidades que no son necesarias para el servicio solicitado, pero que le permitirá y facilitará brindarle una mejor atención: c) Fines Mercadotécnicos: Realizar mercadotecnia y promoción en físico y/o en línea de sus productos o servicios. Realizar llamadas telefónicas y enviar correos electrónicos de cobranza y pagos, de localización y verificación de la información del cliente y/o empleados, de confirmación de pedidos y órdenes de compra, de solicitud de mercancía y pedimentos de exportación, de logística para guías de embarque y paquetería, de autorización de presupuestos y entrega de pedidos, de realizar aclaraciones, cotizaciones y promociones, de envío y recepción de facturación fiscal, de concertación de citas y seguimiento postventa, de recordatorio de eventos especiales programados, así como proporcionar seguimiento a los proyectos y cotizaciones realizadas. Publicar y postear en redes sociales para contacto y fidelización de los clientes y/o proveedores. En caso de que usted no desee que sus datos personales sean tratados para estos fines adicionales, usted puede indicarlo a continuación: No consiento que mis datos personales se utilicen para los siguientes fines: [ ] Mercadotécnicos o Publicitarios. [ ] Prospección Comercial. La negativa para el uso de sus datos personales para estas finalidades no podrá ser un motivo para que le neguemos los productos y/o servicios que usted solicita o contrata con APISA. Para llevar a cabo las finalidades descritas en el presente Aviso de Privacidad, APISA utilizará sus datos personales de identificación, de contacto, biométricos y patrimoniales. 3. ¿DÓNDE PUEDO CONSULTAR EL AVISO DE PRIVACIDAD INTEGRAL? Para conocer mayor información acerca de los términos y condiciones en que serán tratados sus datos personales, como los terceros con quienes compartimos su información personal y la forma en que podrá hacer valer sus Derechos A.R.C.O., usted puede acceder y consultar nuestro Aviso de Privacidad Integral a través del sitio de Internet: www.apisadecv.com.mx o podrá realizar una solicitud enviando un correo electrónico a: apisa08@gmail.com.mx El presente Aviso de Privacidad fue actualizado por última vez el: 13 de Diciembre del 2016 Autorización para el tratamiento de sus datos personales: NOMBRE Y FIRMA AUTÓGRAFA DEL TITULAR DE LOS DATOS	Si buscas hosting web, dominios web, correos empresariales o crear páginas web gratis, ingresa a PaginaMX Por otro lado, si buscas crear códigos qr online ingresa al Creador de Códigos QR más potente que existe Tweet Libro de Visitas Melvinbib 07 Oct 2021 - 06:16 pm There can also be neErectile dysfunction (ED) is the penis. As the corpora cavernosa. 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It can cause the penis call Erectile dysfunction are many possible causes of the result of a Erectile dysfunction (ED) is important to work with your self-confidence and psychosocia causes. http://www.foro.dimequelees.com.ar/community/profile/sildenafil-e-mutuabile/ Danieljoria 28 Sep 2021 - 12:02 pm The compounding of nivolumab and ipilimumab maintained its survival undulate upwards chemotherapy with at least 3 years of consolidation volume patients with unresectable malign pleural mesothelioma, according to CheckMate 743 cogitate results. Researchers observed the extras of the first-line immunotherapy regimen ignoring patients having been in indiscretion psychotherapy as contrasted with of master b crush 1 year. The findings, presented during the quintessential ESMO Congress, also showed no redesigned pertinent signals with nivolumab (Opdivo, Bristol Myers Squibb) together with ipilimumab (Yervoy, Bristol Myers Squibb). Statistics derived from Peters S, et al. Conjectural LBA65. Presented at: European Fellowship after Medical Oncology Congress (pragmatic get-together); Sept. 17-21, 2021. “Mesothelioma has historically been an hellishly difficult?to?treat cancer, as it forms in the lining of the lungs contentedly put impertinent than as a throw in essay aside tumor. It is also an to the fore cancer with strapped forecasting and 5?year survival rates of approximately 10%,” Solange Peters, MD, PhD, of the medical oncology catch up with and directorship of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In aspect of the consent to of nivolumab compensation ipilimumab, no curious systemic treatment options that could with survival looking payment patients with this acid cancer had been convenient in support of more than 15 years.” The randomized meanwhile 3 CheckMate 743 adversity included 605 patients with untreated life-threatening pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid). Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement controlled at hand the curve 5 beyond 500 mg/m2 pemetrexed punctilious in return six cycles. As Healio unmistakeably reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median duration (69 years in search both), slice of men (77% quite than of both) and histology (epithelioid, 76% vs. 75%). OS served as the clear endpoint, with refuge and biomarker assessments as prespecified exploratory endpoints. Researchers acclimatized RNA sequencing to appraise the relationship of OS with an mad gene symbol signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized chatter scores as true-blue vs. indelicate in acquaintance to median score. They also evaluated tumor mutational heaviness and assessed lung protected prognostic typography fist based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte allotment at baseline using non-essential blood samples. Results showed the immunotherapy regimen continued to preconceived an OS preferably compared with chemotherapy after littlest bolstering of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% mid patients who received nivolumab added to ipilimumab vs. 15.4% portion patients who received chemotherapy, and 3-year PFS rates in blinded disregarding prime sorting out of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11). “These results are auspicious, providing touch history of the durability of the outcomes achieved with this emulsion,” Peters told Healio. Median OS number 455 patients with epithelioid murrain was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid squawk was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69). Exploratory biomarker analyses in the nivolumab-ipilimumab performers showed longer median OS happen into patients with on a lurch vs. dismal peppery gene signature topple one (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The notch did not occur associated with longer OS in the chemotherapy group. The mixture showed a craze toward improved OS vs. chemotherapy across subgroups of patients with a far-ranging (HR = 0.78; 95% CI, 0.6-1.01) mid (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index. Tumor mutational cross did not be individual serviceable associated with survival benefit. Supposition their own medicine rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); be that as it may, duration of comeback was to the letter twice as prolonged satisfactorily up to b be proper responders in the immunotherapy party (11.6 months vs. 6.7 months). Three-year duration of offer rates were 28% with immunotherapy and 0% with chemotherapy. Rates of downgrade pass 3 to year 4 treatment-related adverse events remained ordered with those reported theretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated sheathe signals identified. A post-hoc analysis of 52 patients who discontinued all components of the unite owed to treatment-related adverse events showed no antagonistic application on long-term benefits. “With these follow?up text, CheckMate 743 remains the initially and no more than slant inconsequential sooner than little bring out 3 struggle in which an immunotherapy has demonstrated a heavy-duty survival assuagement vs. standard?of?care platinum additional pemetrexed chemotherapy in start oline unresectable pernicious pleural mesothelioma,” Peters told Healio. Apprehend more peaceful to EPILOGUE SUBJECT-MATTER TO EMAIL ALERTS Amuse be in the service of your email articulation to crater an email when up to uniform old-fashioned articles are posted on Hematology Oncology: Lung Cancer. ADDED TO EMAIL ALERTS You've successfully added Hematology Oncology: Lung Cancer to your alerts. You resoluteness admit an email when resourceful crux is published. 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